Hydroxyvalerate) Nanoparticles Prepared by a Miniemulsion/solvent Evaporation Technique. Effect of Phbv Molar Mass and Concentration

Miniemulsification and emulsion/solvent evaporation techniques were combined to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Those nanoparticles were prepared with different PHBV molar masses and PHBV concentrations to verify their effect on the final particle size. Nanoparticles with an average diameter of 133 nm were obtained when a low molar mass (Mw = 44,350 g/mol) polymer was used. On the other hand, when high molar mass PHBV (Mw = 369,900 g/mol) was used under the same operational conditions, nanoparticles with a 300 nm average diameter and a broader particle size distribution were formed. Results also showed that increasing the PHBV concentration led to an increase of the particle size and, when the polymer/costabilizer (PHBV/hexadecane) weight ratio was close to 1, nanocapsules (hexadecane core surrounded by a PHBV shell) were formed.